TOXICITY AND IMMUNOMODULATORY PROPERTIES OF METHANOL EXTRACT OF THE STEM BARK OF LANNEA ACIDA A. RICH. (ANACARDIACEAE) IN WISTAR RATS

📄 Project Abstract

Lannea acidaA. Rich.belongs to the family of Anacardiaceae; and the bark, leaves and roots have been reported to possess many medicinal properties, including immunomodulatory activity.Despite this widespread belief, data on the immunomodulatory properties and safety of this plant is still lacking. The aim of this work was to determine the toxicity and immunomodulatory properties of the stem bark of Lannea acida in Wistar rats. Methanol extract of Lannea acida A. Rich.was screened for phytochemical properties using standard methods. The acute and the subacute (28-day daily repeated dose) toxicity studies were performed using the OECD Fixed Dose Procedure guideline 420 and OECD guideline 407 respectively. To evaluate the immunomodulatory properties, 12 male and 12 female Wistar rats were pre-sensitised with 0.1ml sheep red blood cell intraperitoneally, and subsequently divided into 4 groups of 6 animals each (3 males, 3 females). The first group served as the control while the remaining ...