THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS
📄 Project Abstract
The effect of chloroquine, paracetamol and Promethazine on the pharmacokinetic profile of chlorpropamide was investigated in human subjects. The batches of chlorpropamide, chloroquine, paracetamol and Promethazine used were subjected to quality control studies using official methods. The drugs complied with the B.P (1993) requirements stated in their monographs. A high performance liquid chromatography (HPLC) method was developed for the analysis of plasma chlorpropamide concentration. Pharmacokinetic parameters of chlorpropamide were derived with Winnonlin standard noncompartment software programme. About 16%, 14% and 15% decrease in the mean maximum concentration (Cmax) of chlorpropamide was observed following oral administration of chlorpropamide with chloroquine, paracetamol and Promethazine respectively. About 44%, 11% and 30% decrease in the area under curve (AUC) of chlorpropamide was observed following concurrent administration of chlorpropamide with chloroquine, paracetamol an...
🔍 Key Research Areas Covered
- ✅ Literature Review & Theoretical Framework
- ✅ Research Methodology & Data Collection
- ✅ Data Analysis & Statistical Methods
- ✅ Findings & Results Discussion
- ✅ Recommendations & Conclusions
- ✅ References & Bibliography
📚 Complete Project Structure
- Problem Statement & Objectives
- Theoretical Framework & Related Studies
- Data Collection & Analysis Methods
- Findings & Statistical Analysis
- Recommendations & Future Research
- Questionnaires, Data, References
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THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS
Full Citation:
Uzama Danlami. (). THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS. African and General Studies, 40, 14858.
Citation Formats:
APA
Uzama Danlami. (). THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS. African and General Studies, 40, 14858.
MLA
Uzama Danlami. "THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS." African and General Studies, vol. 40, , pp. 14858.
Chicago
Uzama Danlami. "THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS." African and General Studies 40 (): 14858.
Full Citation:
Uzama Danlami. (). THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS. African and General Studies, 40, 14858.
Citation Formats:
APA
Uzama Danlami. (). THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS. African and General Studies, 40, 14858.
MLA
Uzama Danlami. "THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS." African and General Studies, vol. 40, , pp. 14858.
Chicago
Uzama Danlami. "THE EFFECTS OF CHLOROQUINE, PARACETAMOL AND PROMETHAZINE ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN HUMAN VOLUNTEERS." African and General Studies 40 (): 14858.
Document Details
| Author | Uzama Danlami |
|---|---|
| 📁 Field | Pharmaceutical And Medicinal Chemistry Project Topics |
| 🏷️ Type | Environmental Science Project topics |
| Pages | 213 Pages |
| Words | 29456 words |
| 📘 Chapters | 1 to 5 Chapters |