THE EFFECT OF VITAMIN C ON PHARMACOKINETIC PARAMETERS OF CHLOROQUINE IN HEALTHY HUMAN VOLUNTEERS

📄 Project Abstract

This study was undertaken to compare the effect of vitamin C on the pharmacokinetics of chloroquine using human volunteers. Quality control studies for both chloroquine and vitamin C; identification test, assay, weight variation, friability, disintegration time and dissolution rate were carried out according to BP 2009. Jayanathi et al., 1994 method was adopted and validated based on ICH guideline for this study. Calibration curve was constructed within the range of 2 - 10 g/ml and validated. The adopted method was then employed in determining the effect of vitamin C on the pharmacokinetics parameters (Cmax, Tmax, Ka, Ke, t1/2a, t1/2e, Cl, Vd, lag time and AUC) of chloroquine using human volunteers of 30 years and above and the study was divided into three phases with a washout period of three weeks. Both chloroquine and vitamin C used for this study were found to have the labeled active ingredient. They all passed the assay test as they were within the acceptable limits 95 - 105 %. We...