THE EFFECT OF RIFAMPICIN ON THE PHARMACOKINETIC PARAMETERS OF NIFEDIPINE IN HEALTHY VOLUNTEERS

📄 Project Abstract

Quality assessment of the three brands of nifedipine tablets/capsules were carried out. The identification tests, chemical assay and melting point method, determination showed that all the brands contained nifedipine as active ingredient. The results are in line with BP 1988 Addendun 1990 specifications for identification tests of nifedipine. Using U.V. spectroscopic methods, the U.V. spectra of all brands compared well with that of the reference with absorption maxima; at 206nm. 236nm and 344nm. The estimated total content of active ingredient of the brands of nifedipine using HPLC and U.V.- assay methods gave results which complied with the BP 1988 specification for the drug content (98 - 102%). The disintegration time for all the three brands of the nifedipine was less than 10 minutes. This result complied with BP 1988 specification for tab 1et/capsules disintegration time of not more than 15 minutes. The disssolution rate profiles of the three brands are similar. All the brands rel...