THE EFFECT OF QUININE-ARTESUNATE CO-ADMINISTRATION ON SOME BIOCHEMICAL PARAMETERS IN PLASMODIUM BERGHEI PARASITIZED SWISS ALBINO MICE AND RATS

📄 Project Abstract

Malaria has been the leading cause of morbidity and mortality in most Sub-saharan Africa and Southeastern Asia. Combination therapy has been recommended for treatment of malaria and this could lead to drug-drug interaction. This work titled "The effect of Quinine-Artesunate co-administration on some biochemical parameters on healthy and Plasmodium berghei parasitized Swiss albino mice and rats" was carried out to investigate the effect of Quinine (60 mg/kg)-Artesunate (30 mg/kg) co-administration following 7 days pre treatment. Mice were infected with Plasmodium berghei NK65 strain. Parasitaemia was checked after Geimsa stain and viewed for infected blood cells. Five days of establishment of the infection, they were treated for 7 days. The effect on blood glucose level was evaluated using the glucose oxidase principle; the Liver functions and Oxidative stress were assessed using colorimetric kits. The fasting blood glucose and oral glucose tolerance test of the healthy animals were als...