The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia
📄 Project Abstract
Sickle cell anaemia is an inherited autosomal disease that is very common among people of African, Asian, South European and Middle Eastern descent. The prevalence of sickle cell anaemia in Nigeria is between 1-3%. Vaso-occlusion in sickle cell anaemia is mediated via increased expression of adhesion molecules and is thought to be associated with recurrent or continuous inflammation. Recurrent vaso-occlusion can lead to widespread hypoxia, ischaemia and tissue or organ dysfunction. Micro-RNA 466i up-regulates the expression of interleukin-10(an anti-inflammatory cytokine), by antagonizing the RNA binding protein tristetraprolin, which mediates interleukin-10 messenger RNA degradation. STUDY SETTING This was a cross-sectional study of 50 sickle cell anaemia patients recruited from the out-patient department of University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, South-East Nigeria, between November 2013 and October 2014. They were selected by simple consecutive sampling and cat...
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- Theoretical Framework & Related Studies
- Data Collection & Analysis Methods
- Findings & Statistical Analysis
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- Questionnaires, Data, References
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The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia
Full Citation:
Uchenna S. Anike. (). The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia. African and General Studies, 40, 14858.
Citation Formats:
APA
Uchenna S. Anike. (). The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia. African and General Studies, 40, 14858.
MLA
Uchenna S. Anike. "The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia." African and General Studies, vol. 40, , pp. 14858.
Chicago
Uchenna S. Anike. "The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia." African and General Studies 40 (): 14858.
Full Citation:
Uchenna S. Anike. (). The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia. African and General Studies, 40, 14858.
Citation Formats:
APA
Uchenna S. Anike. (). The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia. African and General Studies, 40, 14858.
MLA
Uchenna S. Anike. "The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia." African and General Studies, vol. 40, , pp. 14858.
Chicago
Uchenna S. Anike. "The Effect Of Micro-Rna 466i On Vaso-Occlusive Complications Of Sickle Cell Anaemia." African and General Studies 40 (): 14858.
Document Details
| Author | Uchenna S. Anike |
|---|---|
| 📁 Field | Anatomic Pathology project topics |
| 🏷️ Type | Medicine Project topics |
| Pages | 73 Pages |
| Words | 12021 words |
| 📘 Chapters | 1 to 5 Chapters |