Study Of The Relationship Between Cd4+ Lymphocyte Count And Absolute Lymphocyte Count In Treatment Naïve Hiv/Aids Patient In Abuth, Zaria

📄 Project Abstract

HIV infection reduces CD4+ T lymphocyte cell count (CCC) and this predisposes to opportunistic infections and associated malignancies. The study analyses the relationship between CD4+ and Absolute lymphocyte count (ALC) with a view to making ALC a surrogate for CCC. There were 20 control, 6 (30%) females and 14 (70%) males. Four hundred (400) adult Nigerians infected with HIV-1 participated in the study. Of these 187 (46.8%) and 213 (53.2%) were males and females respectively. They were assessed clinically and immunologically, and categorized into three clinical stages A, B, and C according to CDC criteria. Blood specimens were taken at enrollment for haematological parameters and CCC. Data was collated and analyzed. One hundred and eight (27%)of the study subjects were in stage A, 153 (38.5%) in stage B, and 139 (34.8%) in stage C. Two hundred and thirteen (53.3%) of the study subjects were in the HIV category while 187 (46.7%)in the AIDS category. The mean ALC of all the study subjec...