Study Of The Effects Of Azadiracta Indica Seed Extract On Blood Glucose Levels Of Normoglycemic And Streptozocin-Induced Diabetic Wistar Rats

📄 Project Abstract

This study investigated the effects of Azadiracta Indica seed extract on blood glucose levels of streptozocin-induced diabetic and normoglycemic Wistar rats. An acute toxicity studies of the extract Azadiracta Indica was done, the result of the acute toxicity study showed that the extract had an LD50 3000mg/kg bodyweight via intraperitoneal route in Wistar rats. A preliminary phytochemical screening was done which revealed the presence of flavonoids tannins, glycerin, cholesterol, steroids alkaloids saponin, triterpenoid and reducing sugar. After which the three doses (500mg/kg, 1000mg/kg and 1500mg/kg bodyweight) of the extract were administered to streptozocin-induced diabetic and normoglycemic Wistar rats. The effects of the extract on blood glucose levels of the animal were compared with untreated control and Biphasic Isophane Insulin treated groups. In the streptozocin-induced diabetic groups, there was no significant change in the blood glucose levels after 1 hour of extract trea...