Storage Iron Status: A Comparison Of Serum Ferritin, Bone Marrow Aspirate And Trephine Biopsy Perl's Stain.

📄 Project Abstract

This prospective study compared serum ferritin and bone marrow trephine iron studies with the results of bone marrow aspirate Perl's stain in consecutive adult patients presenting at the haematology ward and requiring marrow studies. Sixty patients, 35 males (58%) and 25 females (42%), with a mean age of 44 ± 4 years were recruited into the study. Thirty-four (56%) of the patients had human immunodeficiency virus (HIV) infection while the remaining 26 had chronic myeloid leukemia (CML), non-Hodgkin's lymphoma (NHL), severe anaemia or hyperreactive malarial splenomegaly (n = 13, 7, 4 and 2 respectively). Full blood counts (FBC), red cell indices, ESR, blood film microscopy (for malaria parasites and blood cells morphology), ELISA-based serum ferritin concentration (sFC) and bone marrow aspiration (and trephine biopsy, if aspirate is aparticulate) were done. All parameters were analysed for correlation to the sFC values and a p-value < 0.05 was considered significant. There was no statis...