Speciation Of Candida Isolates And Invitro Fluconazole Susceptibility Profile Of Oropharyngeal Candidiasis In People Living With Hiv/Aids In University Of Benin Teaching Hospital, Benin

📄 Project Abstract

Oropharyngeal candidiasis (OPC) is the most prevalent opportunistic fungal infection in people living with HIV/AIDS (PLWHA). In recent times, there have been concerns about the rising incidence of non albicans Candida (NAC) causing this infection. These species also tend to have reduced susceptibility to fluconazole compared with C.albicans. This study investigated the distribution of Candida species in the oral cavities of PLWHA as well as their fluconazole susceptibility profiles. Three hundred and fifty adults with confirmed HIV infection attending the antiretroviral treatment clinic at the University of Benin Teaching Hospital were recruited to participate in the study. Three hundred and fifty HIV-negative voluntary blood donors were recruited as controls. Their oral cavities were sampled using swab sticks and the presence or absence of OPC lesions was noted. Socio-demographic and clinical data were obtained using a structured researcher-administered questionnaire. Isolates of Cand...