SOME UTEROTONIC PROPERTIES OF AQUEOUS LEAF EXTRACT OF SIDA CORYMBOSA (Fries) IN LABORATORY ANIMALS

📄 Project Abstract

Uterotonic property is the characteristic innate ability of a substance to spontaneously initiate and maintain uterine contractions due to its chemical composition. Over centuries, sub-saharan Africans have been using Sida corymbosa leaf extract during labour with the claims that it aids and facilitates childbirth. This study was carried out to validate the folkloric claim that Sida corymbosa leaf extract possesses uterotonic property. Acute toxicity test following single oral administration of the extract was done in accordance with Lorke's method. Preliminary phytochemical screening was carried out in accordance with Odebiyi and sofowora (1978) and of Trease and Evans (1996) methods. In-vitro uterototonic test was conducted on isolated pregnant and non pregnant uterine tissues. The extract, acetylcholine and oxytocin were independently instilled into the organ bath and the responses they elicited were measured on a microdynanometre. Interaction studies were also conducteed using vary...