SOME NEUROPHARMACOLOGICAL PROPERTIES OF METHANOLIC STEM BARK EXTRACT OF FICUS INGENS (MIQUEL) MIQUEL IN MICE AND CHICKS

📄 Project Abstract

Ficus ingens (Miquel) Miquel belongs to the Moraceae family. In some African countries, extracts of the bark are administered to cows with a low milk production, and to people suffering from anaemia, piles and diarrhea. The behavior of living organisms is a visible manifestation of activity of the central nervous system, and mental and behavioural disorders pose a burden to the affected individual and the society at large, and anxiety disorders are inclusive occurring as the most common mental disorder. In this study, the behavioural effects of methanolic extract of Ficus ingens (Miquel) Miquel stem bark were investigated in mice at doses of 75, 150 and 300 mg/kg, using diazepam-induced sleeping time, hole board test, beam walking assay, elevated plus maze, elevated zero maze and staircase test in mice. The results revealed that the extract significantly (P<0.0005) prolonged the duration of diazepam-induced sleep without any effect on the latency to sleep at all the doses tested. The e...