SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1)
📄 Project Abstract
The aim of this study was to enhance the solubility and hence dissolution rate of two poorly soluble drugs: ibuprofen and piroxicam using Eudragit RS 100 and hydroxymethylpropylcellulose (HPMC) as carriers, by solid dispersion technique and to evaluate the effect of trona (sodium sesquicarbonate) on the dispersions . Solid dispersions of ibuprofen and piroxicam were prepared using HPMC or Eudragit RS 100 and their combinations by the solvent evaporation method. The prepared dispersions were characterized with respect to drug content, production yield, moisture sorption and desorption, Fourier Transform Infrared (FT-IR) spectroscopy and differential scanning calorimetry (DSC). The solubilities of the pure drug, solid dispersions and their physical mixtures were studied using standard method. In vitro drug release of ibuprofen and piroxicam from the solid dispersions was evaluated in simulated gastric fluid (SGF) and simulated intestinal fluid (SIF) without enzymes in a sequential fashio...
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- Problem Statement & Objectives
- Theoretical Framework & Related Studies
- Data Collection & Analysis Methods
- Findings & Statistical Analysis
- Recommendations & Future Research
- Questionnaires, Data, References
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SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1)
Full Citation:
Sophie Ishaya Nock. (). SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1). African and General Studies, 40, 14858.
Citation Formats:
APA
Sophie Ishaya Nock. (). SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1). African and General Studies, 40, 14858.
MLA
Sophie Ishaya Nock. "SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1)." African and General Studies, vol. 40, , pp. 14858.
Chicago
Sophie Ishaya Nock. "SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1)." African and General Studies 40 (): 14858.
Full Citation:
Sophie Ishaya Nock. (). SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1). African and General Studies, 40, 14858.
Citation Formats:
APA
Sophie Ishaya Nock. (). SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1). African and General Studies, 40, 14858.
MLA
Sophie Ishaya Nock. "SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1)." African and General Studies, vol. 40, , pp. 14858.
Chicago
Sophie Ishaya Nock. "SOLID DISPERSION AS AN APPROACH FOR SOLUBILITY AND DISSOLUTION ENHANCEMENT OF IBUPROFEN AND PIROXICAM (1)." African and General Studies 40 (): 14858.
Document Details
| Author | Sophie Ishaya Nock |
|---|---|
| 📁 Field | Pharmacology And Therapeutics Project Topics |
| 🏷️ Type | Pharmaceutical Sciences Project Topics |
| Pages | 187 Pages |
| Words | 26590 words |
| 📘 Chapters | 1 to 5 Chapters |