Serum Immunoglobulin Levels In Nigerian Patients With Sickle Cell Anaemia During Bone Pain Crisis And Steady State

📄 Project Abstract

Sickles cell aneamia (SCA) patients are prone to unpredictable recurrent episodes of vaso-occlusive crisis (VOC). VOC is the hall mark of clinical manifestation of sickle cell disease (SCD). Bone pain crisis (BPC) is the most common acute form of VOC, infection is the most common precipitating factor. Immunoglobulin are serum glycoprotein produced by plasma cell that help fight infection. They are important effectors of specific humoral immunity. This study was designed to measure the level of serum immunoglobulin (IgG, IgA, and IgM) in Nigerian sickle cell aneamia patients during BPC and steady state and to ascertain if it has any association on the severity of SCA when compared with other known prognostic factors such as leucocytosis. A total of 100 participants were recruited into the study: subject-50 SCA patients in BPC, 35 of the SCA patients were seen again in steady state four weeks after the initial BPC (served as Auto-control subjects). Control subjects-50 apparently healthy ...