Selected Toxicity Study on Ethanolic Extract of Ocimum gratissimum (Linn.) Leaves in Letrozole-induced Polycystic Ovarian Wistar Rats

📄 Project Abstract

Polycystic Ovarian Syndrome (PCOS) or Stein- Leventhal syndrome is a metabolic endocrine disorder that is very common in women of reproductive age affecting approximately 2-10% of them. Although several synthetic drugs such as metformin are available for the treatment of PCOS, the side effects of the use of metformin such as lactic acidosis have continued to limit their acceptability. Thus, an alternative option of plants like Ocimum gratissimum leaves should be investigated on. The biochemical and toxicological effects of ethanolic extract of Ocimum gratissimum leaves (EEOGL) at the doses of 50 and 100mg/kg body weight on letrozole-induced in Polycystic Ovarian Syndrome (PCOS) was investigated in female Wistar rats. Twenty female Wistar rats with an average weight of (170.81±5.25g) were assigned into 5 groups (A-E) of four each: animals in group A were the control group which received rat pellets and water for 30days while the letrozole-induced rats in groups B, C, D and E also receiv...