Regulation of Reproductive Disorders Associated with Letrozole-Induced Polycystic Ovarian Syndrome in Rats by Ethanolic Extract of Parquetina nigrescens (Afzel

📄 Project Abstract

A variety of illnesses are unique to each gender. The dysfunction of female reproductive organs is referred to as gynaecological problems (Patel, 2018). Although some of these female conditions are treatable, others are lethal, chronic, and have a negative impact on fertility (Patel, 2018). Consequential to the increase in the invasion of and exposure to chemicals that are an endocrine disruptor, hormonal imbalances are becoming more common (Patel, 2018). A few reproductive hormonal abnormalities are amenorrhoea, anovulation, fibroid, endometriosis, polycystic ovarian syndrome, and infertility (Patel, 2018). Polycystic ovarian syndrome is a heterogeneous disorder that affects women of reproductive age (Mikhael et al., 2019). This is a disorder that is principally characterized by signs and symptoms of hyperandrogenism and ovulatory dysfunction which disrupts the function of the hypothalamicpituitary - ovarian (HPO) axis (Baskind and Balen, 2016; Mikhael et al., 2019; Witchel et al., 20...