Phytochemical Analysis of Costus spicatus Flower and In Silico Toxicological evaluation of its Antidiabetic molecule

📄 Project Abstract

Diabetes mellitus is a diverse metabolic disorder which causes modification in the lipid carbohydrate, and protein metabolism (Mutalik et al., 2003). The disorder is caused by the shortage, lack of production of insulin secretion or reduced sensitivity of tissue to insulin, leading to overt hyperglycemia. Hyperglycemia-induced oxidative stress is a crucial etiological factor implicated in Diabetes mellitus (Pong, 2003). In vitro method have been employed for a long time for testing toxicity, However, in vitro toxicity tests became plausible due to the advancement in technology and high throughput screening. In silico toxicology is one type of toxicity assessment that uses computational resources to predict toxicity of chemicals and also in the organization, analysis, modelling, simulation and visualization of compounds. (Deeb and Goodarzi, 2012). In silico pharmacology uses the information obtained from computerized tools to analyze the beneficial or adverse effects of a drug or compon...