PHYTOCHEMICAL ANALYSIS AND EFFECT OF METHANOLIC LEAF EXTRACT OF VERNONIA AMYGDALINA ON LIPID PROFILE IN STREPTOZOTOCIN-INDUCED DIABETIC RATS

📄 Project Abstract

Diabetes mellitus (DM) is positioned seventh among the various leading causes of death and considered third when its fatal complications are attentively regarded ( Ekeocha et al., 2012). Diabetes is one of the major disease that causes death in most countries. It is a chronic disease due primarily to a disorder of carbohydrate metabolism with a deficiency or diminished effectiveness of insulin resulting in chronic hyperglycaemia and glycosuria. (Kumar et al., 2015). Diabetes is also known to be involved in lipid metabolism and oxidative stress( Adewole et al., 2009). Hyperglycaemia causes an increase in oxidative stress, causing inflammation, activation of the polyol pathway, and damage to various organs in the body (Zeinab et al., 2018). Hyperglycemia increases the level of diacylglycerol and activates protein kinase C activity in the aorta of streptozotocin (stz.) induced diabetic rats ( Chattopadhyay et al., 2005). In Nigeria there has been active development of phyto pharmaceutical...