Physiological Responses Of Wistar Rats To Experimentally-Induced Pain During The Harmattan Season And The Modulatory Role Of Resveratrol

📄 Project Abstract

This study investigated the influence of harmattan season (November-February) in naïve animals subjected to mechanical, chemical and thermal noxious stimulation and the modulating effect of resveratrol. Animals were grouped into two major groups of 50 males and females respectively. These major groups were subdivided into control, carboxymethyl cellulose (CMC), resveratrol (RSV) groups with 5 animals each. Different sets of animals were subjected separately to mechanical, chemical and thermal noxious stimulation. Dry bulb temperature readings were taken at 06:00 h, 13:00 h and 18:00 h during the course of the study. After determination of pain thresholds for the three different noxious stimuli, animals were sacrificed and serum was collected for biochemical analyses of sodium, potassium and chloride concentration. Determination of malondialdehyde, superoxide dismutase concentration and erythrocyte osmotic fragility were also carried out. The results obtained revealed that responses to ...