Pattern Of Antiretroviral Drug Resistance In Patients Failing First Line Antiretroviral Drug Resistance In Jos University Teaching Hospital

📄 Project Abstract

Introduction 19 The use of Highly Active Antiretroviral Therapy (HAART) has dramatically improved the quality of life and has reduced the morbidity and mortality of individuals infected with Human Immune Deficiency Virus (HIV). However, antiretroviral drug resistance has become a major challenge to successful antiretroviral therapy. This study was conducted at the HIV Clinic of the Jos University Teaching Hospital between July and December, 2010 to determine the prevalence, pattern and factors associated with antiretroviral (ARV) drug resistance in patients failing first line ARV drugs. Methodology It was a descriptive cross-sectional study; patients failing first line antiretroviral therapy were randomly recruited. Socio-demographic, clinical and laboratory data including genotypic drug resistance mutations were analysed. Results One hundred patients were enrolled, with a mean age of 41±9 years. There were 41 (41%) males and 59 (59%) females. Median CD4+ cell count and HIV viral loads...