MOLECULAR DETECTION OF ADENOVIRUS IN CHILDREN AGE 0-5 PRESENTING DIARRHEA IN OGUN STATE

📄 Project Abstract

Adenoviruses (family Adenoviridae) are non-enveloped viruses with linear double-stranded DNA enclosed by a protein capsid that can cause diseases in humans and other animals (Echavarria, 2009). Adenovirus is a contagious disease that causes respiratory tract infection, gastrointestinal tract infection (GTI) conjunctivitis etc. It is a nonenveloped DNA virus and it belongs to the family Adenoviridae under the genus Mastadenovirus (Kapikan et al., 2001). Human Adenovirus (HAdV) was first discovered by Wallace Rowe and his colleagues in 1953 from an adenoid tissue hence the family name Adenoviridae was created (Hilleman and Werner, 1954; Rowe et al., 1953). An essential characteristic of adenoviruses is their ability to establish latency using the lymphoid tissue of the gut as a reservoir for many species. (Kosulin et al., 2019) There are 52 human adenovirus serotypes (A to G), divided into seven species based on their ability to fuse various types of red blood cells (Jones et al., 2007)....