MOLECULAR CHARACTERIZATION OF MULTIDRUG RESISTANT BACTERIAL UROPATHOGENS FROM PREGNANT WOMEN IN IBADAN METROPOLIS, SOUTH-WEST NIGERIA

📄 Project Abstract

Urinary tract infection (UTI) is one of the commonest infectious diseases of women worldwide, and pregnant women are more predisposed. This study aimed to determine the prevalence of bacterial infecting agents in UTI during pregnancy, to establish their antimicrobial susceptibility profiles, identify the socio-economic factors that promote UTI. Virulence factor genes (VFGs) of the multi-drug resistant bacterial uropathogens were determined in order to establish their pathotypes. Clean catch mid-stream urine samples were collected, processed and analyzed from a total of 650 women on their first visit to antenatal clinics of three major health facilities in Ibadan metropolis. Demographic information was collected using structured questionnaires. Dip-stick leucocyte esterase test was performed and urinary isolates were identified using standard conventional biochemical tests and further confirmed to specie level with Microbact(R) identification kits (Oxoid). Modified Kirby-Bauer disc diff...