Modulatory Role Of Vitamins A And E On Learning, Memory, Motor Strength And Coordination Of Cyanide Induced Neurotoxicity In Albino Mice

📄 Project Abstract

Background: cyanide is a potent neurotoxic substance that can initiate series of intracellular reactions leading to oxidative stress. Objective: To evaluate effect of sublethal administration of KCN on motor functions, visuo-spatial learning and memory. Some biochemical parameters which include brain malondialdehyde concentration, superoxide dismutase, catalase and acetylcholinesterase activities in adult swiss albino mice and possible ameliorative roles of vitamins A and E. Methods: Thirty five adult swiss albino mice weighing between 18-22g were used. In each group served as subjects for this study. An acute toxicity study was carried out and LD50 was calculated as 15mg/kg. The animals were randomly divided into five groups (n = 7) and exposed to sublethal concentration of potassium cyanide (10% LD50; 1.5 mg/kg). The groupings were as follows; group I (control received 10 ml deionised water), group II (1.5mg/kg KCN), group III (1.5mg/kg KCN + 25mg/kg vitamin A), group IV (1.5mg/kg KC...