Modulatory Effect Of Piracetam In Ischaemic Brain Injury On The Cerebrum, Cerebellum And Hippocampus Of Wistar Rat

📄 Project Abstract

Ischaemic brain injuries, that results from stroke, are common and often lead to permanent residual disabilities. This work investigates the role Piracetam, a nootrophic drug, played in modulation of induced brain injury to key areas of the brain; cerebrum, cerebellum and hippocampus of adult Wistar rats. Drugs like Vitamin C, Vitamin E and corticosteroids have been known to improve damage resulting from ischaemic damage to the brain. Piracetam, like wise has been known to improve higher brain functions such as memory and mental alertness. The effect of paracetam was investigated on twenty wistar rats that were divided into five groups of four animals each. Ischaemic brain injury was then induced by transient bilateral occlusion of the carotid arteries. Motor function and memory was assessed and comparison made between those animals that did not receive any drugs and those that received Piracetam and or vitamin E. Serum and brain malonylaldehyde (MDA) levels, histological assessment of...