Investigations Of Activity Of Phenobarbitone In Mice Models Of Depression

📄 Project Abstract

Depression is a severe neurological condition that interferes with our brain neurochemistry and synaptic processes, ultimately leading to intense expression of our emotions. Major fallouts observed from the use of antidepressant including high rates of remission, impotency and suicidal tendencies led to researches to screen other compounds with antidepressant potentials. Various studies have highlighted the antidepressant potential of GABA mimetics such as Barbiturates and Benzodiazepines. This study investigated the antidepressant potential of Phenobarbitone in mice models of depression. A total of 108 Adult male Swiss Albino mice were used throughout the study. The study was conducted in two phases: an acute and a chronic phase respectively. Each mouse received a single intraperitoneal injection of Phenobarbitone 0.5 mg/kg, 2.5 mg/kg, 5 mg/kg and 10 mg/kg respectively. Imipramine 20mg/kg served as the standard drug while distilled water (10 ml/kg) was used as the vehicle. The mice we...