INFLUENCE OF GALLIC ACID ON -AMYLASE AND -GLUCOSIDASE INHIBITORY AND ANTIOXIDANT PROPERTIES OF ACARBOSE

📄 Project Abstract

Diabetes Mellitus (DM) commonly referred to as diabetes is a group of metabolic diseases characterized by hyperglycemia (High blood sugar levels over a prolonged period), either because the pancreas does not produce enough insulin, or because the cells do not respond to the insulin that is produced (David and Gardner, 2011). The main symptoms of high blood sugar include polyuria (frequent urination), polydipsia (increased thirst) and polyphagia (increased hunger). If left untreated, this chronic disease can cause many complications (Cooke and Plotnick, 2008). Type 2 diabetes is the most common form of diabetes (Shi and Hu 2014); it is characterized by insulin resistance, which may be combined with relatively reduced insulin secretion (David and Gardener, 2011), leading to hyperglycemia and ultimately malfunctioning of the pancreatic -cells. Prolonged hyperglycemia results in increased generation of reactive oxygen species (ROS) and alteration of endogenous antioxidants (Ohkuwa et al., ...