INFLUENCE OF AMPICILLIN/CLOXACILLIN ON THE PHARMACOKINETICS OF CHLORPROPAMIDE IN TYPE II DIABETES MELLITUS PATIENTS

📄 Project Abstract

Infection is very common in diabetics and its treatment should be prompt. This study is to examine the influence of ampiclox (Ampicillin/Cloxacillin) Capsules on the pharmacokinetics of chlorpropamide tablets in Type II diabetic patients. Seven type II diabetic patients with age ranging from 35-70 yrs, weight ranging from 55-70 kg and height from 1.65 - 1.78m participated in the study. Each patient received the following treatments at two weeks interval: 250mg Chlorpropamide tablet alone and one 250mg Chloropromede table with one 500mg Ampiclox capsule. Blood samples were taken at intervals for 168hours. Plasma Samples were analysed by sp8 - 100 spectrophotometer. The plasma peak concentration (Cmax), the amount of drug absorbed (AUC) and the elimination half - life (t1/2e[) were all significantly (P<0.05) increased following the second treatment with the lag-time. The statistical analysis was carried out using student t- test for paired data. The elimination rate constant (Ket), the c...