HYPOTENSIVE ACTIVITY AND TOXICOLOGICAL PROFILE OF STEM BARK EXTRACT OF SYZYGIUM GUINEENSE (Willd, D.C. Myrtaceae) IN LABORATORY ANIMALS

📄 Project Abstract

Hypertension of unknown cause is called essential or primary hypertension while hypertension of a known cause is called secondary hypertension. Hypertension is called a silent killer because it is usually asymptomatic. It is a global problem affecting 1 in 3 adults in the United States. It is preventable and treatable disease. Orthodox drugs for its management are expensive and have associated side effects. Alternative source with good efficacy and minimum toxicity from natural products are explored. Hypotensive activity and toxicological profile of methanolic stem bark extract of Syzygium guineense (Willd, D.C. Myrtaceae) were evaluated. It is a medicinal plant used in folk medicine to treat hypertension, diarrhoea and infection. Phytochemical analysis of the stem bark extract was carried out using standard procedures. Bioassy-guided fractionation and finger printing of the crude extract were carried out. Five fractions(SGF1-SGF5) were isolated. The oral and intraperitoneal acute toxi...