HYPOLIPIDEMIC AND ANTIOXIDANT CAPACITY OF METHANOL LEAF EXTRACT OF KIGELIA AFRICANA IN ALLOXAN INDUCED DIABETIC ALBINO RATS

📄 Project Abstract

Diabetic mellitus is a metabolic disorder resulting from a defect in insulin secretion , insulin action or both . The deficiency of insulin leads to chronic hyperglycemia with disturbances of carbohydrate , fats and protein metabolism. Kigelia Africana is a sausage tree known to have medicinal values. The aim of this work is to evaluate the hypolipidemic and antioxidant capacity of the plant , methanol leaf extract of kigelia Africana which was used for the study. The leaves were ground into a powdered form , weighed and soaked with 500ml of methanol for 72hours. It was filtered and the filtrate was concentrated using rotary evaporator at 30 degrees centigrade. Alloxan was induced into 15 male wister albino rats and 5 male wister albino rats were used for the normal control group. They were grouped into four groups : group 1 which was the normal contol group , group 2 was the diabetic rats not treated , group 3 the diabetic rats treated with the standard drug (Glibenclamide) , group...