Evaluation Ofdigitaria Iburua (Family Poaceae) Starch As A Binder And Disintegrant In A Macro-Dose Tablet Formulation.

📄 Project Abstract

The study aims at formulating Paracetamol tablets using Digitaria iburua (DI) starch as binder and disintegrant. Digitaria iburua starch was extracted from Digitaria iburua grains using wet milling and sieving method and thereafter purified. Pregelatinised Digitaria iburua starch (PGS DI) was also prepared. Paracetamol granules were produced by wet granulation method using these two starches as binders and disintegrants and the properties of the granules were compared with gelatin as binder and Maize starch as disintegrant. Properties of the granules and the resulting tablets were determined thereafter compressed into tablets on a single station tablet press. The percentage yield of the starch (DI) extracted was 62.20% w/w while that of (PGS DI) was 73.18% w/w. Digitaria iburua starch when compared with maize starch BP. as tablet binder showed similarity in the values of their moisture content, swelling power, Hausner ratio, tapped and bulk densities. However, there was superiority dis...