EVALUATION OF THE GASTROPROTECTIVE AND SUB-CHRONIC TOXICITY OF METHANOL STEM BARK EXTRACT OF XIMENIA AMERICANA LINN (OLACACEAE) IN MALE WISTAR RATS

📄 Project Abstract

Ximenia americana is a plant used traditionally in northern parts of Nigeria for treatment of leprotic ulcers and mouth ulcers in addition to other medicinal uses. It contains flavanoids, saponins, tannins among others that has been reported to possess gastroprotective potentials. . The aim of this study is to evaluate the gastro-protective effects and establish the toxicity profile of the methanol stem back extract of Ximenia americana. The oral median lethal dose of the extract was estimated in mice and rats using Lorkes method of acute toxicity test, while the composite constituents of the extract were determined using established standard preliminary phytochemical screening procedures of colour changes in test-tube chemical reactions. The antiulcer effect of the extract was evaluated using two ulcerogenic models of indomethacin and ethanol induced ulcers in rats at extract doses of 250, 500 and 1000 mg/kg body weight. Sub-chronic toxicities of the extract on some organs, haematolog...