EVALUATION OF THE EFFECTS OF HYDROMETHANOL EXTRACT AND FRACTIONS OF Crassocephalum rubens ON BLOOD COAGULATION AND CARDIAC PARAMETERS IN ISOPROTERENOL-INDUCED MYOCARDIAL INFARCTED RATS

📄 Project Abstract

Myocardial infarction is a serious cardiac condition that is considered a significant reason for death and morbidity across the world. Atherosclerosis, or the emergence of blood clots in the coronary arteries over time, is the reason. Blood coagulation is a fast and effective process that results in clot formation that needs control. The studies on the effects of hydromethanol extract and fractions Crassocephalum rubens (C. rubens) against blood coagulation profile and concentration of cardiac markers induced by drugs and therapeutic agents remain insufficient, especially its effects on Isoproterenol (ISO.) Special emphasis was given to the impact of C. rubens in blood coagulation cascade and cardiac enzymes concentration where sixty adult male albino rats were used in this study. The animals were divided into twelve equal groups at random. Group I served as control and received 1ml phosphate buffer saline. Group II received ISO and aspirin orally, Group III received ISO without pretre...