Evaluation Of The Effect Of Variations In The Gene Coding For Lipid Desaturase (Fads2) On The Frequency Of Vaso-Occlusive Crisis Among Sickle Cell Anaemia Patients In Enugu, Southeastern Nigeria

📄 Project Abstract

The severity of sickle cell disease (SCD) in terms of frequency of vaso-occlusive crises may be affected by variation in genes coding for enzymes involved in fatty acid metabolism. The understanding of genomic factors that affect disease severity may be enhanced by investigating the relationships between the frequency of sickle-related vaso-occlusive crises and Single Nucleotide Polymorphisms (SNPs) variation in Fatty Acid Desaturase II (FADS2) gene. The aim is to determine the effect of the variation in FADS2 gene on the frequency of painful crises and other clinical correlates in sickle cell anaemia patients in Enugu, Nigeria. This was a cross-sectional study of 100 consecutive sickle cell anaemia patients receiving care at the University of Nigeria Teaching Hospital, Enugu, Nigeria between May 2013 and February 2014.The eligible patients were categorized into two groups namely; group A and group B. Group A (those with moderate to severe crisis), formed the study group comprising tho...