EVALUATION OF THE BINDING PROPERTIES OF ENZYME - HYDROLYZED CASSAVA STARCH IN CHLOROQUINE PHOSPHATE TABLET FORMULATIONS

📄 Project Abstract

Starch is a major carbohydrate, easily extractable from various sources like cassava, maize, potato etc which find wide application in various food and Pharmaceutical industries. There has been a lot of attempt to modify this highly flexible polymer with the aim of extending and enhancing its applications. Native cassava starch (NCS) was extracted from the tubers of freshly harvested cassava. Enzyme- hydrolysed starch (EHS) was produced from Native cassava starch (NCS) using enzymatic hydrolysis method with - amylase as the enzyme. The physicochemical characterization for NCS and EHS was conducted using standard methods, such as flow rate, angle of repose, mean particle size, moisture content, Carrs index, Hausners ratio, ash content, swelling power, pH, bulk and tapped densities. Chloroquine tablets were formulated by wet granulation method and direct compression using EHS, MCC, MS and NCS as binders at different concentrations of 2.5, 5, 7.5 and 10 %w/v. The tablet characteristics w...