Evaluation Of The Anti-Convulsant Effect Of Pennisetum Glaucum Supplement In Some Laboratory Animals

📄 Project Abstract

Pennisetum glaucum has been pharmacologically studied for various activities like antidiabetic, anti-microbial and anti-tumor activities. The present study was aimed at investigating the anti-convulsant effect of Pennisetum glaucum supplement in some laboratory animals. Quantitative phytochemical and proximate tests were carried on Pennisetum glaucum using standard laboratory techniques. In PTZ-induced seizures in mice, 20 swill albino mice were group into 4 negative control which received normal saline, 25% Pennisetum glaucum supplemental group, 50% Pennisetum glaucum supplemental group and diazepam (2 mg/kg) treated group. All the 4 groups received their respective interventions for 14 day. Thirty minutes after the 14th administration freshly prepared PTZ (85 mg/kg) was subcutaneously injected to all the mice and observed for seizure onset, seizure duration, percentage seizure protection and percentage mortality protection for 30 minute post PTZ injection. Induction of PTZ kindling s...