Evaluation Of Prolonged Administration Of Artemether-Lumefantrine On Sperm Indices And Testicular Biomarkers Of Oxidative Stress In Male Wistar Rats Ameliorative Effect Of Vitamin E

📄 Project Abstract

There is frequent use of artemisinin-based combination therapies (ACTs) due to recurrence of malaria infection in Nigeria. The ACTs generate free radicals as part of their mode of action. Reactive oxygen species have been implicated in the etiology of male infertility. In this study, the effect of prolonged administration of artemether-lumefantrine (AL) and the ameliorative effect of vitamin E (VE) on testicular functions and biomarkers of oxidative stress was evaluated. Adult male Wistar rats (n = 35) were divided into five (5) groups of seven (7) rats each and treated as follows: Group I (control): 1ml/kg distilled water; group II: 1ml/kg olive oil; group III: 2.29 mg/13.74 mg/kg AL; group IV: 2.29 mg/13.74 mg/kg AL + 100 mg/kg of VE and group V: allowed to recover from treatment with AL for 2 weeks before sampling (2.29 mg/13.74 mg/kg AL + two weeks recovery). Administration was done orally twice daily for a period of two (2) weeks. At the end of the experiment, animals were sacrifi...