EVALUATION OF MODIFIED STARCHES AND MUCILAGE DISPERSIONS OBTAINED FROM IPOMOEA BATATAS L. LAM (CONVOLVULACEAE) AS BULK EXCIPIENTS IN CHEWABLE TABLET FORMULATIONS

📄 Project Abstract

Increasing attention has been paid to incorporating hydrocolloids into starch-based products due to their unique functional properties and bio-safety. The aim of this work was to determine the suitability of modified starch and mucilage dispersions obtained from Ipomoea batatas as direct compression excipients in chewable tablet. Native starch (SPS) and mucilage were extracted from Ipomoea batatas. Subsequently, SPS was pregelatinized (PPS) and acid modified (APS) and dispersions of mucilage with SPS, PPS and APS in a ratio 1:20, 1:10, 2:10, 3:10 and 4:10 respectively were produced. The dispersions were characterized using standard methods for their particle size, flow properties, moisture sorption capacity, true density, porosity, hydration and swelling capacity. Pasting and thermal properties, syneresis, dilution capacity, lubricant sensitivity, compaction studies using the Heckel and Kawakita parameters, panel assessment of formulated chewable tablets and accelerated stability studi...