EVALUATION OF MODIFIED FINGER MILLET STARCH (Eleusinecoracana L.) AS FILLER/BINDER IN DIRECT COMPRESSION

📄 Project Abstract

Starch modifications are a means of altering the structure and affecting the hydrogen bonding in a controllable manner to enhance and extend their application. There are different methods for modification of starch such as chemical modifications which include stabilization, cross linking, conversions and physical modifications which include annealing and pre-gelatinization. The methods that were chosen to modify Eleusinecoracana starch was by pregelatinization and acid hydrolysis, for the formulation of metronidazole tablets by direct compression. Pregelatinization and acid hydrolysisof the native starch (ORS) was carried out by standard procedures. Acid hydrolysis was allowed for 6h,12h and 18h respectively. Acid hydrolyzed starch was labelled as AHS and pregelatinized starch as PGS. Physicochemical characterization of the native and modified forms of the starch was carried out by several tests. The flow properties of the materials were evaluated by determining the angle of repose, fl...