Evaluation Of Effects Of Hexane And Methanol Extracts Of Trigonella Faenum-Graecum L. On Some Cardiovascular Parameters In Cats And Rabbits

📄 Project Abstract

Trigonella Foenum-gaecum L. contains a broad spectrum of therapeutic properties. It is used as galactagogue and antidiabetic among others in traditional medicine practice. Effects of methanol and hexane extracts of the seeds of Trigonella Foenum-gaecum L. on blood pressure was evaluated in normotensive male adult cats. Intravenously administered doses: (0.1 mg/ml, 1mg/ml, 10 mg/ml and 100 mg/ml) of the extracts to anaesthetized normotensive cats produced decrease in mean diastolic, and systolic and mean arterial pressures in a graded dose response manner but the decrease was significant as on the dose of 100mg/ml on diastolic blood pressure 14.50 ± 0.50 mmHg (hexane extract) and 13.50 ± 2.50 mmHg (methanol extract) while dose of Ach 10g/ml produced a fall in mean diastolic, systolic, and means arterial pressure of 13.5 ± 2.50 mmHg, 22 ± 4.0 mmHg, and 16.3 ± 2.5 mmHg respectively. Atropine (25mg/ml) at all tolerable doses did not block the hypotensive effect of both extracts but rather ...