Evaluation Of Co-Administration Of Ethyl Acetate Fraction Of Cannabis Sativa Leaves And Ethanol On Learning, Memory And The Histomorphology Of The Hippocampus In Mice (Mus Musculus)

📄 Project Abstract

Substance abuse especially amongst young adults constitutes a global problem. Cannabis sativa is a commonly abused illicit drug. Some of its effects include impaired short memory, attention and reduced motor skills. Ethanol is a multiple action depressor of the central nervous system and under its influence, confused and disorganized thinking results. Both drugs have a detrimental effect on prospective memory in adults but users may not be aware of this. This study was therefore aimed at evaluating the co-administration of ethyl acetate fraction of Cannabis sativa leaves and ethanol on Learning, Memory and the histomorphology of the Hippocampus in Mice (Mus Musculus) using the Y-maze and Novel Object Recognition (NOR) paradigms. Fourty eight apparently healthy male albino mice of 20-28 g body weight were assigned into two major groups consisting of four sub-groups each; A, B, C, and D. Each sub group had six mice each (n=6). Sub-groups A, B, C, and D were administered distilled water 1...