EVALUATION OF A CO-PROCESSED EXCIPIENT FROM COW BONE POWDER AND GELATIN FOR USE IN DIRECT COMPRESSION TABLETING

📄 Project Abstract

The objective of the study was to develop an excipient consisting of cow bone powder and gelatin by the co-processing method and to evaluate its use in direct compression tablet formulation. Co-processing is based on the novel concept of two or more excipients interacting at the sub particle level, the objective of which is to provide a synergy of functionality improvement as well as masking the undesirable properties of individual excipients. Fresh cow femur and tibia bones were collected and cut into pieces using an axe and boiled to about 100 degrees C to remove all traces of fat, meat and bone marrow and was subsequently washed with hot water. The bones were then dried and subjected to heating to produce the cow bone powder in an industrial furnace at about 600 degrees C to 800 degrees C for 6 h and then pulverized. Gelatin was dissolved in a beaker with 20 ml of water using gallenkamp regulator hot plate at a temperature of about 100 degrees C and incorporated into wet activat...