Effects Of Prenatal Administration Of Monosodium Glutamate On The Developing Cerebrum Of Wistar Rats

📄 Project Abstract

Effects of a flavor enhancer, monosodium glutamate (MSG) was evaluated in female albino rats during the gestational period. Thirty two rats were divided into 4 equal groups (each having 8 rats), Group I, control; Group II, treated with 6 g/kg/day of MSG, Group III, treated group with 8 g/kg/day and Group IV received 10 g/kg/day of MSG. Different doses of MSG (6 g/kg, 8 g/kg and 10 g/kg body weight) were administered orally from 7 -15th day of gestational period on completion of the treatment period. The Dams were allowed to deliver their pups. Sixty four pups were used for histology and the remaining were used for motor activity. Morphometric results of the fetal weight ,crown rump length, head of the pups, brain weight, weight of the cerebral cortex, cerebral width (narrow area) and cerebral width (broad area) of the developing cerebral cortex showed that high dose group rats demonstrated significant reduction in all the parameters when compared to the control. MSG also induced some a...