Effects Of Lycopene On Blood Glucose And Physiological Parameters Of Streptozotocin-Induced Diabetic Wistar Rats

📄 Project Abstract

Diabetes mellitus is a major health problem in the world and is diagnosed by the presence of sustained high glucose levels in the blood. Oxidative stress is known to be actively involved in the onset and progression of diabetes and its complications. Antioxidants have important roles in biological systems by scavenging free radicals which may result in oxidative damage of biological molecules such as lipids, proteins and DNA. The aim of the study was to investigate the effects of lycopene on blood glucose level and some physiological parameters of streptozotocin-induced hyperglycaemic Wistar rats as model. The animals were made diabetic by single intraperitoneal injection of STZ (60 mg/kg). Diabetes was confirmed by the presence of high blood glucose 200 after 72 hours. Thirty Wistar rats of both sexes were used in the study of which twenty five of them were diabetic. They were divided into six groups (1, 2, 3, 4, 5 and 6) comprising five animals each. Animals in Group 1 (Diabetic con...