EFFECTS OF CO-ADMINISTRATION OF SITAGLIPTIN AND ETHANOL LEAF EXTRACT OF MORINGA OLEIFERA LAM. IN ALLOXAN-INDUCED DIABETES MELLITUS AND ITS CHRONIC COMPLICATIONS IN RATS

📄 Project Abstract

Incidence and prevalence of type 2 diabetes mellitus (T2DM), with its resultant complications continue to be on the increase. The outcome of management is highly dependent on efficacy, safety and suitability of medicines used concomitantly. An aspect of efficacy/safety that is of growing importance is that of drug-herb interactions. The co-administration of Sitagliptin, an antidiabetic agent and Moringa oleifera, a herb traditionally used in the management of T2DM is a real possibility in the diabetic population. This study investigated the effects of co-administration of Sitagliptin (50 mg/kg) and ethanol leaf extract of M. oleifera (300 mg/kg) on the onset, progression and amelioration of diabetic complications in alloxan-induced diabetic rats. Six groups of eight rats per group were used, with groups I and II as normal (NC) and diabetic controls (DC). Groups III to VI were diabetic rats treated with Sitagliptin (III), M. oleifera (IV), Sitagliptin and M. oleifera (SM) (V), in two ph...