EFFECTS OF CO-ADMINISTRATION OF PROMETHAZINE AND ARTEMETHER-LUMEFANTRINE IN PLASMODIUM berghei berghei INFECTED MICE

📄 Project Abstract

Malaria is the 2nd leading cause of death from infectious diseases in Africa, after HIV/AIDS. It is a major public health problem in Nigeria where it accounts for most cases of hospital visits and deaths than any other country in the world. This study evaluated the effects of co-administration of promethazine and Artemether-Lumenfantrine in mice infected with Plasmodium berghei berghei. The mice were grouped into six groups of 6 mice each. Group 2 - 6 were inoculated with Plasmodium berghei berghei groups. Drug administration was carried out orally and for 5 days, 72 hours after parasite inoculation and parasitaemia seen. The mice were sacrificed on the 8th day. Blood samples were collected and organs harvested for haematological and histopathological evaluations. Parameters evaluated include average parasitaemia inhibition, haematological indices, organ-body weight ratio and liver transaminases. The liver, kidney and heart were subjected to histological evaluation. The result showed t...