EFFECTS OF Carica papaya (Linn) LEAVES ON LIPID PROFILE AND BLOOD CLOTTING OF STZ INDUCED DIABETIC RATS

📄 Project Abstract

Diabetes Mellitus (DM) is a group of metabolic disorders characterized by varying or persistent hyperglycemia resulting from insufficient action of insulin. It is observed as the body's incapacity to efficiently regulate the sugar balance which leads to severe complications, pancreatic damage resulting in the dysfunction of alpha and beta cells causes disordered glucose homeostasis. This study intends to evaluate the effect of Carica papaya leaf methanol extract on plasma blood glucose, lipid profile, bleeding time and clotting time of STZ induced diabetic rats. Thirty male Wistar rats were randomly divided into five groups and administered different doses of the extract for 14 days while normal control and diabetic control received distilled water. The plasma glucose concentration and lipid profile in the blood plasma of experimental animals were determined using Randox Kits; 20l of samples and standard were mixed with 200l of working reagent and incubated at 37 degrees C for 10minute...