EFFECTS OF ADMINISTRATION OF CARBAMAZEPINE, PHENYTOIN AND THEIR COMBINATION ON NEUROBEHAVIOURAL, COGNITIVE HAEMATOLOGICAL AND SERUM BIOCHEMICAL CHANGES IN ALBINO RATS

📄 Project Abstract

The aim of the study was to evaluate the neurobehavioural patterns, cognitive functions and haemato-biochemical changes following the administration of carbamazepine (CBZ), phenytoin (PHE) and their combination. Forty, apparently healthy adult male Albino rats weighing between 144 and 300 g were divided into four groups of 10 animals each and used for the experiment. Group I (control) were administered distilled water per os at the dose rate of 10 mls/kg and they served as untreated control. CBZ at 20 mg/kg, PHE at 100 mg/kg and a combination of CBZ and PHE at 20 mg/kg and 100 mg/kg were administered per os to groups II, III and IV respectively. The regimens were given once daily for a period of eight weeks and the rats were monitored for neurobehavioural changes and cognitive functions using the method as described by Zhu et al., 2001. Blood and serum samples were collected for evaluation of full blood count, total protein, albumin, globulin, urea and some electrolytes. Alanine aminot...