EFFECT OF Phyllanthus amarus AND N-HEXADECANOIC ACID ON BLOOD COAGULATION PARAMETERS OF LIPOPOLYSACCHARIDE-INDUCED INFLAMMATION IN WISTAR RATS

📄 Project Abstract

Blood clotting is a complex sequence of processes involving multiple proteins (factors) that must operate in a specific order to create a clot. The procedure is rapid and effective, but it must be monitored because uncontrolled clotting can lead to thrombosis. A shift in the balance of blood coagulation and coagulation inhibition, favoring either pro- or anticoagulation, can result in life-threatening thromboembolism or bleeding. This study evaluated the effect of ethanol Phyllanthus amarus extract and n-hexadecanoic acid on blood coagulation parameters of lipopolysaccharide-induced inflammation in Wistar rats. Thirty rats were used for the study and were divided into six different groups with each group containing five rats. Oral administration of plant extract lasted for twenty-one days after which inflammation was induced in the rats with a single dose of lipopolysaccharide (1 mg/kg) intraperitoneally. Blood coagulation parameters like prothrombin time (PT), activated partial thromb...