EFFECT OF GREEN TEA (CAMELLIA SINENSIS) ON THE PHARMACOKINETIC PROFILE OF CEPHALEXIN IN HEALTHY HUMAN VOLUNTEERS

📄 Project Abstract

Tea is a herb commonly consumed globally. Herbs are often taken concurrently with conventional medicines which results in increased potential of drug-herb interactions, and this may have important clinical significance based on an increasing number of reports of such interactions. This research work, determines the effects of green tea (Camellia sinensis) on the pharmacokinetic profile of cephalexin in healthy human volunteers. Quality control studies were conducted on a sample of cephalexin (500 mg) capsule to establish identity, weight uniformity, disintegration time, dissolution, and as well as assay using the methods of BP 1993 and BP 2013.A UV spectrophotometric method for determining cephalexin in plasma using water as a solvent at pH 4 was developed and validated based on international conference on harmonization (ICH) guidelines. For the in vivo study, six apparently healthy human volunteers were used throughout the study. The study involved four phases with one week washout pe...