Effect Of Ethanol Extract Of Vernonia Amygdalina Leaf In Cerebral And Cerebellar Cortices Of Young Mice Inoculated With Plasmodium Berghei

📄 Project Abstract

Malaria is the world's most important parasitic disease especially when Plasmodium falciparum is the cause of most of the mortality and morbidity. Malaria has been challenging human health and losing the lives of many people since long period of time. Malaria has been one of the most extensively studied parasitic infectious diseases for millennia and the recent failure of chemotherapy through parasite resistance to drugs and alternative therapy is paramount. The present study was aimed at evaluating the effect of ethanol extracts of vernonia amygdalina leaf in cerebral and cerebellar cortices of young mice inoculated with plasmodium berghei. Sixty (60) young mice aged 5-7 weeks, weighing between 10-15g were divided into three categories in which category A, B, C contain twenty mice each which represent the Suppressive, Curative, and the Prophylactic design. Each category contains five groups with four mice in each group. In all the categories each Group 1 was administered distilled wat...